DomperidoneA peripheral D2DR inhibitor

Domperidone (CAS 57808-66-9)

Domperidone | CAS 57808-66-9 is rated 5.0 out of 5 by 1.
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Application: A peripheral D2DR inhibitor
CAS Number: 57808-66-9
Purity: ≥99%
Molecular Weight: 425.91
Molecular Formula: C22H24ClN5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Domperidone is a selective inhibitor of the peripheral D2DR. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.


References

1. Niemegeers, C.J., et al. 1980. Arch Int Pharmacodyn Ther. 244: 130-140. PMID: 7416883
2. Prakash, A. and Wagstaff, A.J. 1998. Drugs. 56: 429-445. PMID: 9777316
3. Osinski, M.A., et al. 2005. Pharmacol. Biochem. Behav. 81: 211-219. PMID: 15894081

Physical State :
Solid
Solubility :
Slightly soluble in water
Storage :
Store at 4° C
Melting Point :
236-239° C
Refractive Index :
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE2275900
PubChem CID :
3151
Merck Index :
14: 3418
MDL Number :
MFCD00069256
EC Number :
260-968-7
Beilstein Registry :
903774
SMILES :
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Osinski et al Osinski et al. (PubMed ID 15894081) found that the dopamine D2-like receptor, domperidone blocked the emetic response to PNU95666E, a dopamine D2 receptor selective agonist, in ferrets. -SCBT Publication Review
Date published: 2015-03-09
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