Dolastatin 15An apoptotic agent through Blc-2 phosphorylation

Dolastatin 15 (CAS 123884-00-4)

Dolastatin 15 | CAS 123884-00-4 is rated 5.0 out of 5 by 1.
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Application: An apoptotic agent through Blc-2 phosphorylation
CAS Number: 123884-00-4
Purity: ≥98%
Molecular Weight: 837.06
Molecular Formula: C45H68N6O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare Dolabella auricularia with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits Tubulin-dependent GTP hydrolysis to Tubulin but has been shown to bind to the RZX/MAY region. The compound acts as a weak Tubulin inhibitor by binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.


References

1. Bai, R., et al. 1992. Biochem. Pharmacol. 43: 2637-2645. PMID: 1632820
2. Hu, Z.B., et al. 1993. Leuk. Res. 17: 333-339. PMID: 8487581
3. Maki, A., et al. 1995. Anticancer Drugs. 6: 392-397. PMID: 7670136
4. Ali, M.A., et al. 1998. Anticancer Res. 18: 1021-1026. PMID: 9615758
5. Cruz-Monserrate, Z., et al. 2003. Eur. J. Biochem. 270: 3822-3828. PMID: 12950266

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at -20° C
Boiling Point :
954.01° C at 760 mmHg
Density :
1.21 g/cm3
Refractive Index :
n20D 1.57
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
357989
MDL Number :
MFCD00236968
SMILES :
CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)O[C@@H](C(C)C)C(=O)N3[C@H](C(=CC3=O)OC)CC4=CC=CC=C4)NC(=O)[C@H](C(C)C)N(C)C

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Certificate of Analysis

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Dolastatin 15  Product Citations

See how others have used Dolastatin 15. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25633196  Cho, YC. et al. 2015. Cell Death Differ. 22: 1605-17.

PMID: # 22623379  Piplani, H. et al. 2013. Mol. Carcinog. 52: 845-58.

PMID: # 23872169  Piplani, H. et al. 2013. Biochimica et biophysica acta. 1830: 5142-56.

PMID: # 22441428  Piplani, H. et al. 2012. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 21: 511-22.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Piplani Piplani, H. et al. (PubMed 23872169) reported that the apoptotic agent Dolastatin, along with celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. -SCBT Publication Review
Date published: 2015-04-22
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