DolasetronAn antiserotonin compound

Dolasetron (CAS 115956-12-2)

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Application: An antiserotonin compound
CAS Number: 115956-12-2
Molecular Weight: 324.37
Molecular Formula: C19H20N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dolasetron is an antiserotonin used as an antiemetic to prevent nausea and vomiting brought on by chemotherapy or general anaesthesia. Dolasetron is an inhibitor of SR-3A.


References

Hesketh PJ, Gandara DR, Hesketh AM et al. Support Care Cancer. 4:141-146 (1996). Fujii Y. Clin Drug Investig. 26:427-437 (2006).

Physical State :
Solid
Solubility :
Soluble in water, ethanol, chloroform, DMSO, and methanol.
Storage :
Store at room temperature
Melting Point :
278° C
Boiling Point :
535.1° C
Density :
1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
HERG: IC50 = 12.02 µM (human)
pK Values :
pKb: 6.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NL6014644
PubChem CID :
3148
MDL Number :
MFCD00865542
SMILES :
O=C(OC1CC2CC3CC(C1)N2CC3=O)C1=CNC2=CC=CC=C12

Download SDS (MSDS)

Certificate of Analysis

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