Anti-Dok-1 Antibody (A-3) is a mouse monoclonal IgG1 κ Dok-1 antibody, cited in 18 publications, provided at 200 µg/ml
raised against amino acids 1-276 mapping at the N-terminus of Dok-1 of mouse origin
Anti-Dok-1 Antibody (A-3) is recommended for detection of Dok-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
Anti-Dok-1 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Dok-1 (A-3): sc-6929.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dok-1 Antibody (A-3) for WB and IHC(P) applications. These reagents are now offered in bundles with Dok-1 Antibody (A-3) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Dok-1 Antibody (A-3) is a high quality monoclonal Dok-1 antibody (also designated DOK1 antibody) suitable for the detection of the Dok-1 protein of mouse, rat and human origin. Dok-1 Antibody (A-3) is available as both the non-conjugated anti-Dok-1 antibody form, as well as multiple conjugated forms of anti-Dok-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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