DNA-PK Inhibitor IIAn antiproliferative agent, and inhibitor of DNA-PK

DNA-PK Inhibitor II (CAS 154447-35-5)

DNA-PK Inhibitor II | CAS 154447-35-5 is rated 5.0 out of 5 by 1.
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Synonym: NU7026; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
Application: An antiproliferative agent, and inhibitor of DNA-PK
CAS Number: 154447-35-5
Purity: >98%
Molecular Weight: 281.31
Molecular Formula: C17H15NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.


References

1. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269: 5241-5248. PMID: 8106507
2. Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13: 3083-3086. PMID: 12941339
3. Veuger, S.J., et al. 2003. Cancer Res. 63: 6008-6015. PMID: 14522929
4. Willmore, E., et al. 2004. Blood. 103: 4659-4665. PMID: 15010369

Physical State :
Solid
Solubility :
Soluble in DMSO (3 mg/ml) at 60° C, methanol (700 µg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
175.74° C (Predicted)
Boiling Point :
459.88° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
DNA-PK: IC50 = 0.23 µM; PI 3-K: IC50 = 13 µM; ATM: IC50 = >100 µM; ATR: IC50 = >100 µM
pK Values :
pKb: 0.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9860529
MDL Number :
MFCD06798345
SMILES :
O=c1cc(oc2c1ccc1ccccc21)N1CCOCC1

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Certificate of Analysis

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DNA-PK Inhibitor II  Product Citations

See how others have used DNA-PK Inhibitor II. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27129079  Boichuk, S. et al. 2016. Anticancer Drugs. 27: 620-34.

PMID: # 23939025  2013. Mol. Ther. 21: 2205-16.

PMID: # 15010369  Willmore, E. et al. 2004. Blood. 103: 4659-4665.

PMID: # 14522929  Veuger, SJ. et al. 2003. Cancer Res. 63: 6008-6015.

PMID: # 14522929  Veuger, SJ. et al. 2003. Cancer Res. 63: 6008-6015.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Willmore et al (PubMed ID 15010369) found the DNA Willmore et al (PubMed ID 15010369) found the DNA-PK inhibitor II potentiated a concentration-dependent increase in etoposide-induced double strand breaks by inhibiting adequate cell cycle arrest. -SCBT Publication Review
Date published: 2015-05-07
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