DMXAAAn apoptosis inducer for proteomics research

DMXAA (CAS 117570-53-3)

DMXAA | CAS 117570-53-3 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_207592, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 56ms
  • REVIEWS, PRODUCT
Synonym: Vadimezan
Application: An apoptosis inducer for proteomics research
CAS Number: 117570-53-3
Molecular Weight: 282.295
Molecular Formula: C17H14O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

DMXAA is an apoptosis inducer, and an anti-vascular. DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), DMF (~14 mg/ml), 1:1 solution of DMF: PBS (pH=7.2) (~0.5 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
189.81° C (Predicted)
Boiling Point :
~520.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
VEGFR2: IC50 = 11 µM; DT-diaphorase: IC50 = 62.5 µM; VEGFR1: IC50 = 119 µM; ADMET: IC50 = 134.6 µM; Mus musculus: IC50 = 211.4 µM; C13 cell line: IC50 = 614.7 µM
Ki Data :
DT-diaphorase: Ki= 20 µM
pK Values :
pKa: 4.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ZD5536200
PubChem CID :
123964
MDL Number :
MFCD00870555
SMILES :
CC1=C(C)C2=C(C=C1)C(=O)C1=C(O2)C(CC(O)=O)=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the purity of your DMXAA

Asked by: Axel
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26

What is the solubility of DMXAA in chloroform?

Asked by: Man0696
The solubility in chloroform is not available. Solubility in other recommended solvents is available on our website.
Answered by: Technical Support
Date published: 2018-12-21

Is it photosensitive?

Asked by: Man0696
Thank you for your question. DMXAA: sc-207592 is not light sensitive.
Answered by: Technical Support
Date published: 2018-12-05

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. DMXAA, sc-207592, is in white to off-white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-06-23
  • y_2019, m_9, d_18, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_4
  • loc_en_US, sid_207592, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 245ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Pan et al Pan et al. (PubMed ID 25733813) found that DMXAA (Vadimezan), a potent tumor blood-vessel disrupting agent and cytokine inducer, promoted intracellular ROS production in non-small cell lung cancer A549 cells conducive to apoptosis. -SCBT Publication Review
Date published: 2015-07-09
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_207592, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.