DMSA (Meso-2,3-dimercaptosuccinic acid)CAS: 304-55-2
MF: C4H6O4S2
MW: 182.22
A water-soluble chelating agent.

DMSA (Meso-2,3-dimercaptosuccinic acid) (CAS 304-55-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 156ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A water-soluble chelating agent
CAS Number: 304-55-2
Purity: 97%
Molecular Weight: 182.22
Molecular Formula: C4H6O4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.


1. Vineeta, N., et al. 2001. J Indian Soc Pedod Prev Dent. 19: 160-163. PMID: 12396095
2. Kramer, H.J., et al. 2003. Biochem. Pharmacol. 65: 1741-1746. PMID: 12754110
3. Bradberry, S., et al. 2009. Clin Toxicol. 47: 617-631. PMID: 19663612
4. Bradberry, S., et al. 2009. QJM. 102: 721-732. PMID: 19700440
5. Azevedo, R.B., et al. 2011. Cell Adh Migr. [Epub ahead of print]. PMID: 20935452

Physical State :
Solubility :
Soluble in water, and ethanol (25 mg/ml, Colorless to Light Yellow, Clear).
Storage :
Store at -20° C
Melting Point :
196-198° C (lit.)(dec.)
Boiling Point :
~267.6° C at 760 mmHg (Predicted)
Density :
1.62 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α25/D 0°±1°, c = 1 in DMF
pK Values :
pKa: 2.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 8865
MDL Number :
EC Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

DMSA (Meso-2,3-dimercaptosuccinic acid)  Product Citations

See how others have used DMSA (Meso-2,3-dimercaptosuccinic acid). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30929137  Acar, T.|Kaya, E.|Yoruk, MD.|Duzenli, N.|Senturk, RS.|Can, C.|Ozturk, L.|Tomruk, C.|Uyanikgil, Y.|Rybicki, FJ.| et al. 2019. Jpn J Radiol. 37: 458-465.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 81ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 31ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.