DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.
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See how others have used DMSA (Meso-2,3-dimercaptosuccinic acid). Click on the entry to view the PubMed entry .
PMID: # 30929137 Acar, T.|Kaya, E.|Yoruk, MD.|Duzenli, N.|Senturk, RS.|Can, C.|Ozturk, L.|Tomruk, C.|Uyanikgil, Y.|Rybicki, FJ.| et al. 2019. Jpn J Radiol. 37: 458-465.
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