DMCM hydrochloride CAS: 82499-00-1
MF: C17H18N2O4•HCl
MW: 350.8
A benzodiazepine inverse agonist.

DMCM hydrochloride (CAS 82499-00-1)

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Alternate Names: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Application: DMCM hydrochloride is a benzodiazepine inverse agonist
CAS Number: 82499-00-1
Molecular Weight: 350.8
Molecular Formula: C17H18N2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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DMCM hydrochloride is a benzodiazepine inverse agonist. Exhibits strong convulsant and anxiogenic activity. DMCM hydrochloride is an inhibitor of GABA Receptor.


References

Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117. Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180. Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Plasmodium falciparum W2 : IC50 = 7.94 µM; Plasmodium falciparum GB4: IC50 = 12.59 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UU9780280
PubChem CID :
MDL Number :
MFCD10687107
SMILES :
CCC1=C2C3=CC(=C(C=C3NC2=CN=C1C(=O)OC)OC)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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DMCM hydrochloride (CAS 82499-00-1)  Product Citations

See how others have used DMCM hydrochloride (CAS 82499-00-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26577018  Kratsman, N.|Getselter, D.|Elliott, E.| et al. 2016. Neuropharmacology. 102: 136-45.

PMID: # 32328689  Anal Bioanal Chem. 4037-4043.

Citations 1 to 2 of 2 total
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