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YangYang, Q. et al. (PubMed 15257901) found that inhibition of glucosylceramide synthase (GCS) and mdr1 gene expressions is positively correlated with the concentrations of DL-PPMP and verapamil, which can reverse multidrug resistance (MDR) by inhibiting synthesis of GCS and mdr1 gene, indicating the positive correlation between the expression of GCS gene and MDR in KBV(200) cells. -SCBT Publication Review
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