DL-PPMPAn inhibitor of glucosylceramide synthetase

DL-PPMP (CAS 149022-18-4)

DL-PPMP | CAS 149022-18-4 is rated 5.0 out of 5 by 1.
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Synonym: DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride
Application: An inhibitor of glucosylceramide synthetase
CAS Number: 149022-18-4
Purity: ≥98%
Molecular Weight: 511.18
Molecular Formula: C29H50N2O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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DL-PPMP inhibits UGCG (glucosylceramide synthase) and is more effective than PDMP in intact cells.


References

1. Abe, A., et al. 1992. J. Biochem. 111: 191-196. PMID: 1533217

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, and water.
Storage :
Store at -20° C
Refractive Index :
n20D 1.51
pK Values :
pKa: 13.60, pKb: 6.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
49837889
MDL Number :
MFCD00211157
SMILES :
CCCCCCCCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@@H](C2=CC=CC=C2)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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DL-PPMP  Product Citations

See how others have used DL-PPMP. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26678556  Mikami, J.|Tobisawa, Y.|Yoneyama, T.|Hatakeyama, S.|Mori, K.|Hashimoto, Y.|Koie, T.|Ohyama, C.|Fukuda, M.| et al. 2016. Cancer Sci. 107: 359-68.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yang Yang, Q. et al. (PubMed 15257901) found that inhibition of glucosylceramide synthase (GCS) and mdr1 gene expressions is positively correlated with the concentrations of DL-PPMP and verapamil, which can reverse multidrug resistance (MDR) by inhibiting synthesis of GCS and mdr1 gene, indicating the positive correlation between the expression of GCS gene and MDR in KBV(200) cells. -SCBT Publication Review
Date published: 2015-03-29
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