DL-AP7A potent NMDA receptor antagonist

DL-AP7 (CAS 78966-69-5)

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Synonym: DL-2-Amino-7-phosphonoheptanoic acid
Application: A potent NMDA receptor antagonist
CAS Number: 78966-69-5
Purity: ≥97%
Molecular Weight: 225.2
Molecular Formula: C7H16NO5P
* Refer to Certificate of Analysis for lot specific data (including water content).
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DL-AP7 is a competitive antagonist of the ionotropic glutamate receptor, NMDA. Studies indicate that the S1 and S2 domains of the NMDA receptor are essential in DL-AP7 and other related antagonists to bind to the receptor. In addition, the positively charged Lys residues at the second interaction site and Arg at the fourth site are key factors in ligand binding. The NMDA receptor is unique in that it requires binding of two ligands, glutamate and glycine to become activated. As a result of its inhibitory affects, DL-AP7 is an ideal tool in studying signaling pathways and ion flow through the NMDA receptor.


References

1. Laube, B., et al. 1997. Neuron. 18: 493-503. PMID: 9115742
2. Liu, Y. and Zhang, J. 2000. Chin. Med. J. 113: 948-956. PMID: 11775847
3. Blaise, M.C., et al. 2005. J Mol Model. 11: 489-502. PMID: 15928921

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM).
Storage :
Store at 4° C
Melting Point :
222-226° C
Boiling Point :
480.13° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 388 nM (rat)
Ki Data :
Glutamate NMDA receptor: Ki= 912 nM (rat)
pK Values :
pKa: 2.54 (Predicted), pKb: 9.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MJ1927500
PubChem CID :
3122
MDL Number :
MFCD00055057
Beilstein Registry :
3544152
SMILES :
C(CCC(C(=O)O)N)CCP(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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