DL-2-Amino-5-phosphonovaleric acid (DL-AP5) is an N-methyl-D-aspartate (NMDA; sc-200458) receptor antagonist. Interference of this compound with NMDA receptors has shown to be the mechanism behind its potent and selective antagonistic characteristic towards synaptic and amino-acid induced excitation. Additionally, in brain synapsic studies DL-AP5 has been reported to reverse NMDA inhibition of glutamate release evoked by 4-aminopyridine (sc-202421).
1. Davies, J. and Watkins, J.C. 1982. Brain Res. 235: 378-386. PMID: 6145492
2. Sequeira, S.M., et al. 2001. Brain Res. Mol. Brain Res. 89: 111-118. PMID: 11311981
3. Vigh, J. and Witkovsky, P. 2004. Vis. Neurosci. 21: 1-11. PMID: 15137577
See how others have used DL-2-Amino-5-phosphonovaleric acid (AP5). Click on the entry to view the PubMed entry .
PMID: # 29162813 Lalonde, J. et al. 2017. Nat Commun. 8: 1659.
PMID: # 27522962 O'Brien, M. et al. 2016. Neuroscience. 334: 236-244.
PMID: # 24704516 Wong, H. et al. 2014. Neuroscience. 269: 232-44.
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