DL-2-Amino-4-phosphonobutanoic acid (AP4)An amino-acid derivative reported to block cone signals in the rat retina

DL-2-Amino-4-phosphonobutanoic acid (AP4) (CAS 20263-07-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 70ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: DL-AP4; DL-2-Amino-4-phosphonobutanoic acid
Application: An amino-acid derivative reported to block cone signals in the rat retina
CAS Number: 20263-07-4
Purity: ≥99%
Molecular Weight: 183.10
Molecular Formula: C4H10NO5P
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

DL-2-Amino-4-phosphonobutanoic acid (AP4) is a broad spectrum EAA ligand and amino-acid derivative. An NMDA agonist/antagonist reported to block cone signals in the rat retina. DL-2-Amino-4-phosphonobutanoic acid (AP4) is also known to be a synaptic depressant. See separate isomers (sc-200429 and sc-200432).


References

1. Evans, R.H., et al. 1979. Br. J. Pharmacol. 67: 591-603. PMID: 316343
2. Koerner, J.F., et al. 1981. Brain Res. 216: 192-198. PMID: 6266585
3. Slaughter, M.M., et al. 1981. Science. 211: 182-185. PMID: 6255566
4. Evans, R.H., et al. 1982. Br. J. Pharmacol. 75: 65-75. PMID: 7042024
5. Davies, J., et al. 1982. Brain Res. 235: 378-386. PMID: 6145492
6. Kleinrok, Z., et al. 1985. Pol J Pharmacol Pharm. 37: 575-584. PMID: 3008130
7. Collingridge, G.L., et al. 1989. Pharmacol. Rev. 41: 143-210. PMID: 2558391
8. Hansen, J.J., et al. 1990. Med Res Rev. 10: 55-94. PMID: 2153264
9. Green, D.G., et al. 2007. Vis. Neurosci. 24: 9-15. PMID: 17430605

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), NaOH, dilute aqueous base, and ethanol.
Storage :
Store at room temperature
Melting Point :
225-228° C
Boiling Point :
~491.7° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Metabotropic glutamate receptor 8: IC50 = 5.1 nM (human); Metabotropic glutamate receptor 6: EC5050 = 280 nM (human); Metabotropic glutamate receptor 4: EC5050 = 330 nM (human)
pK Values :
pKa: 2.19 (Predicted), pKb: 9.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ES7191700
PubChem CID :
2207
MDL Number :
MFCD00013999
Beilstein Registry :
2093908
SMILES :
C(CP(=O)(O)O)C(C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 56ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 57ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.