DisulfiramAn ALDH and tumor cell growth inhibitor

Disulfiram (CAS 97-77-8)

Disulfiram | CAS 97-77-8 is rated 5.0 out of 5 by 1.
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Synonym: Tetraethylthiuram disulfide
Application: An ALDH and tumor cell growth inhibitor
CAS Number: 97-77-8
Purity: ≥97%
Molecular Weight: 296.54
Molecular Formula: C10H20N2S4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase.


References

1. Brady, J.F., et al. 1991. Toxicol. Appl. Pharmacol. 108: 366-373. PMID: 1850173
2. Schroeder, J.P., et al. 2010. Neuropsychopharmacology. 35: 2440-2449. PMID: 20736996
3. Lin, J., et al. 2010. Prostate. [Epub ahead of print]. PMID: 20809552
4. Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945

Physical State :
Solid
Solubility :
Soluble in water (4 mg/l at 25° C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile.
Storage :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
117.2° C at 17 mmHg
Density :
1.3 g/cm3
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
MCF7: IC50 = 0.1 µM (human); T47D: IC50 = 0.17 µM (human); MDA-MB-231: IC50 = 0.32 µM (human); Adenosine A3-R: IC50 = 0.36 µM (human); D3DR: IC50 = 1.08 µM (human)
Ki Data :
Adenosine A3-R: Ki= 0.2 µM (human); D3DR: Ki= 0.37 µM (human); CKR-2B: Ki= 0.95 µM (human); D1DR: Ki= 1.08 µM (human); D4DR: Ki= 1.11 µM (human)
pK Values :
pKb: 0.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JO1225000
PubChem CID :
3117
Merck Index :
14: 3364
MDL Number :
MFCD00009048
EC Number :
202-607-8
Beilstein Registry :
1712560
SMILES :
CCN(CC)C(=S)SSC(=S)N(CC)CC

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Disulfiram  Product Citations

See how others have used Disulfiram. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26577527  Mali, VR. et al. 2016. Cell. Signal. 28: 1-6.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 21035945) used disulfiram to inhibit aldehyde dehydrogenase and found that this inactivated proteasome activity and induced cancer cell apoptosis. -SCBT Publication Review
Date published: 2015-07-13
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