Diphtheria Toxin A catalyst of the ADP-ribosylation of EF-2 and a protein synthesis inhibitor.

Diphtheria Toxin

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Alternate Names: Diphtheria Toxin is known as an intact toxin.
Application: Diphtheria Toxin is an intact toxin catalyst of the ADP-ribosylation of EF-2 and a protein synthesis inhibitor.
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diphtheria Toxin, from Corynebacterium diphtheriae, inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II (EF-2). Diphtheria Toxin is cell permeable and can translocate across endosomal membranes in response to low pH3. Diphtheria Toxin is synthesized and excreted as a proenzyme and must undergo two covalent alterations in order to be active. LD50 - Intraperitoneal: 0.0065 mg/kg (hamster) ; 0.0003 mg/kg (mouse). LD50 - Subcutaneous: 0.0003 mg/kg (mouse)


References

1. Ladokhin, A.S.pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain. Toxins (Basel) 5(8), 1362-1380 (2013).
2. Murphy, J.R.Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. Toxins (Basel) 3(3), 294-308 (2011).
3. Bütepage, M., Eckei, L., Verheugd, P., et al.Intracellular mono-ADP-ribosylation in signaling and disease. Cells 4(4), 569-595 (2015).

Usage :
Not recommended for in-vivo use.
Appearance :
Lyophilized powder
Physical State :
Solid
Derived From :
Corynebacterium diphtheriae
Solubility :
Soluble in water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD00163490

Download SDS (MSDS)

Certificate of Analysis

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このDiphtheria Toxinは、Nestin-ERTCre/ROSA26-DTR-floxマウスなどで欠損マウスを作成したい場合でも使用可能なのでしょうか?

Asked by: maki
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Answered by: Technical Support 8
Date published: 2018-01-24
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