Diphtheria Toxin, from Corynebacterium diphtheriae, inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II (EF-2). Diphtheria Toxin is cell permeable and can translocate across endosomal membranes in response to low pH3. Diphtheria Toxin is synthesized and excreted as a proenzyme and must undergo two covalent alterations in order to be active. LD50 - Intraperitoneal: 0.0065 mg/kg (hamster) ; 0.0003 mg/kg (mouse). LD50 - Subcutaneous: 0.0003 mg/kg (mouse)
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