Diphtheria Toxin, CRM Mutant CAS: 92092-36-9
MW: 63000

Diphtheria Toxin, CRM Mutant (CAS 92092-36-9)

Diphtheria Toxin, CRM Mutant | CAS 92092-36-9 is rated 5.0 out of 5 by 1.
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Alternate Names: [Glu52]-Diphtheria toxin from Corynebacterium diphtheriae; CRM 197
Application: Diphtheria Toxin, CRM Mutant is an agent that does not have NAD:EF2 ADP-ribosyltransferase activity
CAS Number: 92092-36-9
Molecular Weight: 63000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diptheria Toxin, CRM Mutant, also known as CRM197, does not have NAD:EF2 ADP-ribosyltransferase activity due to an amino acid substitution of glycine to glutamic acid, that results in the alteration of the NAD+ binding site, in fragment A. The non-toxic diptheria toxin, CRM197, can inhibit bladder smooth muscle cell proliferation through its interaction with HB-EGF. Research shows that CRM197 does not catalyze ADP ribosylation of elongation factor-2 (EF-2), and failed to induce apoptosis in Vero cells in the presence of brefeldin and okadaic acid (sc-3513). Both the mutant CRM197 and the wild type diptheria toxin are alike immunologically.


References

1. Giannini, G., et al. 1984. Nucleic Acids Res. 12: 4063-4069. PMID: 6427753

2. Bixler, G.S., et al. 1989. Adv. Exp. Med. Biol. 251: 175-180. PMID: 2481959

3. Gupta, R.K., et al. 1997. Vaccine. 15: 1341-1343. PMID: 9302741

4. Kaefer, M., et al. 2000. J. Urol. 163: 580-584. PMID: 10647689

5. Kusano, I., et al. 2001. Cell Struct. Funct. 26: 279-288. PMID: 11831360

Physical State :
Solid
Solubility :
Soluble in water, and aqueous buffers.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XW5807200
PubChem CID :
MDL Number :
MFCD00166638

Download SDS (MSDS)

Certificate of Analysis

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PMID: # 6427753  Giannini, G. et al. 1984. Nucleic Acids Res. 12: 4063-4069.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hu Hu, Y. et al. (PubMed 25201410) reported that CRM197 in combination with shRNA interference of VCAM-1 displays enhanced inhibitory effects on human glioblastoma cells. -SCBT Publication Review
Date published: 2015-02-11
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