Dimethyl-W84 dibromideA potent allosteric modulator of muscarinic receptors also selective for M2-receptors

Dimethyl-W84 dibromide (CAS 402475-33-6)

Dimethyl-W84 dibromide | CAS 402475-33-6 is rated 5.0 out of 5 by 1.
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Application: A potent allosteric modulator of muscarinic receptors also selective for M2-receptors
CAS Number: 402475-33-6
Purity: 98%
Molecular Weight: 736.58
Molecular Formula: C34H48Br2N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dimethyl-W84 dibromide is a very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Dimethyl-W84 dibromide retards the dissociation of the antagonist N-methylscopolamine. pKA=7.08, p(αKA)=6.75, pEC50,diss=6.77.


References

1. Trankle, C., et al. Mol. 1998. Pharmacol. 54: 139-145. PMID: 9658199
2. Li, R., et al. 2001. Arch. Pharm. 334: 121-124. PMID: 11382147
3. Trankle, C., et al. 2003. Mol. Pharmacol. 64: 180-190. PMID: 12815174
4. Voigtlander, U., et al. 2003. Mol. Pharmacol. 64: 21-31. PMID: 12815157
5. Staudt, M., et al. 2003. Arch. Pharm. 336: 385- 389. PMID: 14502759
6. Trankle, C., et al. 2005. Mol. Pharmacol. 68: 1597-1610. PMID: 16157694

Physical State :
Solid
Solubility :
Soluble in water, DMSO, and aqueous buffer.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD08702721
SMILES :
[Br-].[Br-].Cc1ccc2C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)c4cc(C)ccc4C3=O)C(=O)c2c1

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Certificate of Analysis

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Rated 5 out of 5 by from Tr nkle C; et al Tr nkle C; et al. (PubMed ID: 12815174) determined that Dimethyl-W84 dibromide decreased its affinity for allosteric site on M2 muscarinic receptors when exposed to Tacrine and Duo3. -SCBT Publication Review
Date published: 2015-02-05
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