Date published: 2026-1-14

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Dimethyl ethylidenemalonate (CAS 17041-60-0)

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CAS Number:
17041-60-0
Molecular Weight:
158.15
Molecular Formula:
C7H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dimethyl ethylidenemalonate (DME) is a synthetic compound widely utilized in laboratory applications as a reagent for synthesis and as a catalyst in organic reactions. The mechanism of action of Dimethyl ethylidenemalonate centers around its function as an inhibitor of the enzyme phosphorylase kinase, which holds significant involvement in the regulation of cell growth. Through binding to the enzyme, Dimethyl ethylidenemalonate effectively hinders its catalytic activity, preventing the phosphorylation of proteins. As phosphorylation is essential for cellular growth and division, this inhibition acts as a deterrent to cell proliferation.


Dimethyl ethylidenemalonate (CAS 17041-60-0) References

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  2. Catalytic asymmetric Michael reactions with enamides as nucleophiles.  |  Berthiol, F., et al. 2007. Angew Chem Int Ed Engl. 46: 7803-5. PMID: 17768749
  3. Selective deoxygenative alkylation of alcohols via photocatalytic domino radical fragmentations.  |  Guo, HM. and Wu, X. 2021. Nat Commun. 12: 5365. PMID: 34508098
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  6. Photochemical synthesis of some propellanes through [2+ 2] cycloaddition of indeno [2, 1-a] indene with several olefins  |  Shim, S. C., Chae, J. S., & Choi, J. H. 1983. The Journal of Organic Chemistry. 48(4): 417-421.
  7. Palladium-catalyzed [3+ 2] cycloaddition reaction of vinylcyclopropanes with α, β-unsaturated esters or ketones  |  Shimizu, I., Ohashi, Y., & Tsuji, J. 1985. Tetrahedron letters. 26(32): 3825-3828.
  8. Efficient method for the synthesis of 1, 4-disubstituted 5-carbomethoxypyrimidin-6-ones  |  Veale, C. A., Steelman, G. B., & Chow, M. M. 1993. The Journal of Organic Chemistry. 58(16): 4490-4493.
  9. A Versatile Synthesis of Acridine-1, 9-Diones  |  Chen, J., & Deady, L. W. 1997. Synthetic communications. 27(1): 95-106.
  10. Photocycloaddition Reactions of Pyrazinopsoralen with Simple Olefins  |  Han, G. S., & Shim, S. C. 1998. Photochemistry and photobiology. 67(1): 84-89.
  11. Carbon–carbon bond forming reactions of N-bound transition metal α-cyanocarbanions: a mechanistic probe for catalytic Michael reactions of nitriles  |  Naota, T., Tannna, A., & Murahashi, S. I. 2001. Chem. Commun. (1): 63-64.
  12. Catalytic Enantioselective Michael Reaction of 1, 3‐Dicarbonyl Compounds via Formation of Chiral Palladium Enolate  |  Hamashima, Y., Hotta, D., Umebayashi, N., Tsuchiya, Y., Suzuki, T., & Sodeoka, M. 2005. Advanced Synthesis & Catalysis. 347(11‐13): 1576-1586.
  13. Selective Michael additions to alkylidenemalonates using thiourea-based bifunctional organocatalysts  |  Gavin, D. P., & Stephens, J. C. 2013. Arkivoc. 4: 76-87.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dimethyl ethylidenemalonate, 5 g

sc-227891
5 g
$112.00