dimethoxy CurcuminAn analog of curcumin more effective at suppressing HCT116 tumor cells than the parent compound

dimethoxy Curcumin (CAS 160096-59-3)

dimethoxy Curcumin | CAS 160096-59-3 is rated 5.0 out of 5 by 1.
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Synonym: 1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione
Application: An analog of curcumin more effective at suppressing HCT116 tumor cells than the parent compound
CAS Number: 160096-59-3
Purity: >90%
Molecular Weight: 396.4
Molecular Formula: C23H24O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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dimethoxy Curcumiin is an analog of curcumin which was obtained by the methylation of both free phenolic groups in the parent compound. Phytochemicals such as turmeric (curcumin) have been found to inhibit the growth of tumor cells. With this addition, a 30-fold increase in potency was observed in the growth suppression of HCT116 tumor cells.


References

1 Ohori, H., Yamakoshi, H., Tomizawa, M., et al. Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Molecular Cancer Therapeutics 5(10) 2563-2571 (2006).

Physical State :
Solid
Solubility :
Soluble in ethanol (~0.25 mg/ml), DMSO (~5 mg/ml), DMF (~10 mg/ml), DMF:PBS (pH 7.2) (1:2) (~0.30 mg/ml), and water (0.30 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
212.12° C (Predicted)
Boiling Point :
587.01° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Trypanosoma brucei brucei 427 : EC5050 = 450 nM; SKBR3 cells: IC50 = 955 nM (human); MCF7: IC50 = 1.07 µM (human); Chloroquine-sensitive Plasmodium falciparum FCK2: IC50 = 7.86 µM; Chloroquine-resistant Plasmodium falciparum MP14: IC50 = 8.40 µM
pK Values :
pKa: 8.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9952605
MDL Number :
MFCD22123809
SMILES :
COC1=C(C=C(C=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Lu Lu, J. et al. (PubMed 22986236) reported that dimethoxy Curcumin could ameliorate mitochondrial dysfunction in mutated TDP-43 stably transfected cell lines. -SCBT Publication Review
Date published: 2015-03-12
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