dimethoxy Curcumiin is an analog of curcumin which was obtained by the methylation of both free phenolic groups in the parent compound. Phytochemicals such as turmeric (curcumin) have been found to inhibit the growth of tumor cells. With this addition, a 30-fold increase in potency was observed in the growth suppression of HCT116 tumor cells.
1 Ohori, H., Yamakoshi, H., Tomizawa, M., et al. Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Molecular Cancer Therapeutics 5(10) 2563-2571 (2006).
Soluble in ethanol (~0.25 mg/ml), DMSO (~5 mg/ml), DMF (~10 mg/ml), DMF:PBS (pH 7.2) (1:2) (~0.30 mg/ml), and water (0.30 mg/ml at 25° C).
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LuLu, J. et al. (PubMed 22986236) reported that dimethoxy Curcumin could ameliorate mitochondrial dysfunction in mutated TDP-43 stably transfected cell lines. -SCBT Publication Review
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