Dihydrofluorescein diacetate CAS: 35340-49-9
MF: C24H18O7
MW: 418.40
A chemical hydrolyzed by cellular esterases.

Dihydrofluorescein diacetate (CAS 35340-49-9)

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Alternate Names: Fluorescin diacetate; Diacetyldihydrofluorescein
Application: Dihydrofluorescein diacetate is a chemical hydrolyzed by cellular esterases
CAS Number: 35340-49-9
Molecular Weight: 418.40
Molecular Formula: C24H18O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Dihydrofluorescein diacetate is a chemical used for intracellular staining. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as 2',7'-dichlorodihydrofluorescein (sc-477276) and Dihydrorhodamine 123 (sc-203027). Dihydrofluorescein diacetate is first hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by hydrogen peroxide (sc-203336).


References

1. Hempel, S L., et al., 1999. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free radical biology & medicine. 27(1-2): 146-59. PMID: 10443931

Physical State :
Solid
Storage :
Store at room temperature
Melting Point :
213-215° C (lit.)
Boiling Point :
~554.3° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00005056
Beilstein Registry :
364167
SMILES :
CC(=O)OC1=CC2=C(C=C1)C(C3=C(O2)C=C(C=C3)OC(=O)C)C4=CC=CC=C4C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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