Dihydroergocristine mesylateAn ergot alkaloid serotonin receptor antagonist

Dihydroergocristine mesylate (CAS 24730-10-7)

Dihydroergocristine mesylate | CAS 24730-10-7 is rated 5.0 out of 5 by 1.
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Synonym: Dihydroergocristinmesilat
Application: An ergot alkaloid serotonin receptor antagonist
CAS Number: 24730-10-7
Purity: ≥98%
Molecular Weight: 707.84
Molecular Formula: C35H41N5O5•CH3SO3H
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dihydroergocristine mesylate is a semisynthetic ergot alkaloid with effects on memory and cognition. Dihydroergocristine mesylate demonstrates antagonism at SR (serotonin receptors) and partial agonism/antagonism of dopaminergic and adrenergic receptors. Enhancement of spatial learning, acquisition of avoidance behavior, and retention of passive avoidance response were observed in aged rats exposed to Dihydroergocristine mesylate. Amphoteric vasoregulating activity is also observed with Dihydroergocristine mesylate, where hypotensive effects are noted in hypertensive animals and hypertensive effects noted in hypotensive animals.


References

1. Drago, F., et al. 1988. Pharmacol. Biochem. Behav. 30: 961-965. PMID: 3147464
2. Coppi, G. 1992. Arzneimittelforschung. 42: 1381-1390. PMID: 1492857
3. Bicalho, B., et al. 2005. Curr. Drug Metab. 6: 519-529. PMID: 16379666

Physical State :
Solid
Solubility :
Soluble in water (10 mg/mL), methanol (22 mg/mL), and DMSO (25 mM).
Storage :
Store at room temperature
Melting Point :
213-215° C
IC50 :
Trypanosoma cruzi: EC5050 = 5000 nM
pK Values :
pKa: 9.61 (Predicted), pKb: 7.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
KE7600000
PubChem CID :
444034
Merck Index :
14: 3653
MDL Number :
MFCD00153792
EC Number :
246-434-6
SMILES :
CC(C)[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5C[C@H]6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C.CS(=O)(=O)O

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Certificate of Analysis

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Dihydroergocristine mesylate  Product Citations

See how others have used Dihydroergocristine mesylate. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 1492857  Coppi, G. et al. 1992. Arzneimittelforschung. 42: 1381-1390.

PMID: # 3147464  Drago, F. et al. 1988. Pharmacol. Biochem. Behav. 30: 961-965.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Lee HG; et al Lee HG; et al. (PubMed ID: 25233863) utilized Dihydroergocristine mesylate, a -2 adrenergic receptor antagonist to study tianeptine's mechanism of action in male Sprague-Dawley rats. -SCBT Publication Review
Date published: 2015-05-08
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