Dihydro-D-erythro-Sphingosine (CAS 764-22-7)

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Alternate Names: D-erythro-Dihydrosphingosine; D-erythro-Sphinganine, C18 chain

Application: Dihydro-D-erythro-Sphingosine is a sphingosine biosynthetic precursor

CAS Number: 764-22-7

Molecular Weight: 301.5

Molecular Formula: C₁₈H₃₉NO₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Dihydro-D-erythro-Sphingosine: sc-203911...

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Dihydro-D-erythro-Sphingosine is a biosynthetic precursor of sphingosine that inhibits PKC (protein kinase C) in Chinese hamster ovary cells (IC₅₀ = 2.8 μM). Dihydro-D-erythro-Sphingosine also directly inhibits PLA2 (phospholipase A2) and PC-PLD (phospholipase D). Dihydro-D-erythro-Sphingosine is a substrate of SphK.

References

Yung, B.Y., et al. 1994. Biochem. Biophys. Res. Commun. 199, 888. Franson, R.C., et al. 1992. Biochim. Biophys. Acta 1136, 169. Merrill, A.H., Jr. 1989. Biochemistry 28, 3138. Lambeth, J.D., et al. 1988. J. Biol. Chem. 263, 3818. Hannun, Y., and Bell, R.M. 1987. Science 235, 670. Ganong, B., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 1184. Merrill, A.H., et al. 1986. J. Biol. Chem. 261, 12610.

Physical State :

Solid

Solubility :

Soluble in ethanol(warm) (25 mg/ml), DMSO(warm) (25 mg/ml), dichloromethane, ethyl acetate, and methanol.

Storage :

Store at -20° C

Melting Point :

180° C

Boiling Point :

446.21° C at 760 mmHg (Predicted)

Density :

0.93 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.48 (Predicted)

IC50 :

Plasmodium falciparum: IC₅₀ = 12.59 µM; CETP: IC₅₀ = 12.9 µM (human); UBC13: IC₅₀ = 13.38 µM (human); protein kinase C (PKC): IC₅₀ = 2.8 µM (Chinese hamster ovary cells); Jurkat: IC₅₀ = 3.53 µM (human)

pK Values :

pK_a: 12.57 (Predicted), pK_b: 8.57 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

PubChem CID :

91486

MDL Number :

MFCD07371371

SMILES :

CCCCCCCCCCCCCCCC(C(CO)N)O

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Dihydro-D-erythro-Sphingosine (CAS 764-22-7)

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References

Download SDS (MSDS)

Certificate of Analysis