Dihydro-D-erythro-Sphingosine CAS: 764-22-7
MF: C18H39NO2
MW: 301.5
A sphingosine biosynthetic precursor.

Dihydro-D-erythro-Sphingosine (CAS 764-22-7)

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Alternate Names: D-erythro-Dihydrosphingosine; D-erythro-Sphinganine, C18 chain
Application: Dihydro-D-erythro-Sphingosine is a sphingosine biosynthetic precursor
CAS Number: 764-22-7
Molecular Weight: 301.5
Molecular Formula: C18H39NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dihydro-D-erythro-Sphingosine is a biosynthetic precursor of sphingosine that inhibits PKC (protein kinase C) in Chinese hamster ovary cells (IC50 = 2.8 μM). Dihydro-D-erythro-Sphingosine also directly inhibits PLA2 (phospholipase A2) and PC-PLD (phospholipase D). Dihydro-D-erythro-Sphingosine is a substrate of SphK.


References

Yung, B.Y., et al. 1994. Biochem. Biophys. Res. Commun. 199, 888. Franson, R.C., et al. 1992. Biochim. Biophys. Acta 1136, 169. Merrill, A.H., Jr. 1989. Biochemistry 28, 3138. Lambeth, J.D., et al. 1988. J. Biol. Chem. 263, 3818. Hannun, Y., and Bell, R.M. 1987. Science 235, 670. Ganong, B., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 1184. Merrill, A.H., et al. 1986. J. Biol. Chem. 261, 12610.

Physical State :
Solid
Solubility :
Soluble in ethanol(warm) (25 mg/ml), DMSO(warm) (25 mg/ml), dichloromethane, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
180° C
Boiling Point :
446.21° C at 760 mmHg (Predicted)
Density :
0.93 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 12.59 µM; CETP: IC50 = 12.9 µM (human); UBC13: IC50 = 13.38 µM (human); protein kinase C (PKC): IC50 = 2.8 µM (Chinese hamster ovary cells); Jurkat: IC50 = 3.53 µM (human)
pK Values :
pKa: 12.57 (Predicted), pKb: 8.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD07371371
SMILES :
CCCCCCCCCCCCCCCC(C(CO)N)O

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Certificate of Analysis

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