DifluoromethylornithineAn inhibitor of ornithine decarboxylase

Difluoromethylornithine (CAS 70052-12-9)

Difluoromethylornithine | CAS 70052-12-9 is rated 5.0 out of 5 by 1.
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Synonym: 2,5-diamino-2-(difluoromethyl)pentanoic acid; Eflornithine; 2-(Difluoromethyl)ornithine
Application: An inhibitor of ornithine decarboxylase
CAS Number: 70052-12-9
Purity: ≥98%
Molecular Weight: 182.17
Molecular Formula: C6H12F2N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Difluoromethylornithine is an irreversible inhibitor of ornithine decarboxylase (ODC) which has antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis.


References

Gupta S, Ahmad N, Marengo SR. Cancer Res. 60:5125-33 (2000). Takahashi Y, Mai M, Nishiojka K. Int. J Cancer 85:243-7 (2000). Meyskens FL Jr, Gerner EW. J Cell Biochem Suppl. 22:126-31 (1995).

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water. Insoluble in chloroform, and acetone.
Storage :
Store at -20° C
Melting Point :
297.69° C (Predicted)
Boiling Point :
~347.04° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.46
IC50 :
Trypanosoma brucei rhodesiense: IC50 = 3.8 µM; Leishmania donovani: IC50 = 50 µM; Trypanosoma brucei brucei: IC50 = 2.27 µg/ml; L6: IC50 = 12 µg/ml (rat); MRC5: IC50 = >100 µg/ml (human)
Ki Data :
Ornithine decarboxylase: Ki= 39 µM (rat)
pK Values :
pKa: 1.22 (Predicted), pKb: 10.45 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3009
MDL Number :
MFCD00221766
Beilstein Registry :
2250529
SMILES :
C(CC(C(F)F)(C(=O)O)N)CN

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Certificate of Analysis

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Difluoromethylornithine  Product Citations

See how others have used Difluoromethylornithine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27452468  2016. Cell Rep. 16: 1604-1613.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from LeGendre LeGendre-McGhee S; et al. (PubMed ID: 26396545) determined that Difluoromethylornithine decreased cell proliferation and K-RAS mutation frequency in colon tumorigenesis in mice. -SCBT Publication Review
Date published: 2015-05-02
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