DiethylmaleateA glutathione-depleting compound that inhibits NF kappa B

Diethylmaleate (CAS 141-05-9)

Diethylmaleate | CAS 141-05-9 is rated 5.0 out of 5 by 1.
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Synonym: Maleic acid diethyl ester
Application: A glutathione-depleting compound that inhibits NF kappa B
CAS Number: 141-05-9
Purity: ≥97%
Molecular Weight: 172.2
Molecular Formula: C8H12O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diethylmaleate is a glutathione-depleting compound that has been shown to induce apoptosis. Reports indicate that Diethylmaleate inhibits NF κ B activation, activates PDAP1 (Pap1), and modifies the endoribonuclease action of 26S proteasomes. Diethylmaleate is an activator of GHS-R1α.


References

1. Horton, N.D., et al. 1999. J. Biol. Chem. 274: 9200-9206. PMID: 10092592
2. Tsimokha, A.S., et al. 2006. Tsitologiia. 48: 133-141. PMID: 16737180
3. Kang, M.H., et al. 2007. FEMS Microbiol. Lett. 275: 270-277. PMID: 17725619
4. Tsimokha, A.S., et al. 2007. Tsitologiia. 49: 451-459. PMID: 17802742

Physical State :
Liquid
Solubility :
Soluble in 100%ethanol, ether, alcohol, and diethyl ether. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
-10° C (lit.)
Boiling Point :
225° C (lit.)
Density :
1.07 g/cm3 at 25° C
Refractive Index :
n20D 1.44
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
ON1225000
PubChem CID :
5271566
Merck Index :
14: 3123
MDL Number :
MFCD00009191
EC Number :
205-451-9
Beilstein Registry :
1100825
SMILES :
CCOC(=O)C=CC(=O)OCC

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Certificate of Analysis

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Diethylmaleate  Product Citations

See how others have used Diethylmaleate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23426973  Maryon, EB. et al. 2013. Am. J. Physiol., Cell Physiol. 304: C768-79.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Tsimokha Tsimokha, AS. et al. (PubMed 17802742) reported that treatment of K562 cells with Diethylmaleate led to modification of zeta/alpha5 and iota/alpha6 proteasomal subunits associated with RNAse activity of proteasomes. -SCBT Publication Review
Date published: 2015-02-07
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