Diethylmaleate is a glutathione-depleting compound that has been shown to induce apoptosis. Reports indicate that Diethylmaleate inhibits NF κ B activation, activates PDAP1 (Pap1), and modifies the endoribonuclease action of 26S proteasomes. Diethylmaleate is an activator of GHS-R1α.
1. Horton, N.D., et al. 1999. J. Biol. Chem. 274: 9200-9206. PMID: 10092592
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TsimokhaTsimokha, AS. et al. (PubMed 17802742) reported that treatment of K562 cells with Diethylmaleate led to modification of zeta/alpha5 and iota/alpha6 proteasomal subunits associated with RNAse activity of proteasomes. -SCBT Publication Review
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