Diethylmaleate is a glutathione-depleting compound that has been shown to induce apoptosis. Reports indicate that Diethylmaleate inhibits NF κ B activation, activates PDAP1 (Pap1), and modifies the endoribonuclease action of 26S proteasomes. Diethylmaleate is an activator of GHS-R1α.
1. Horton, N.D., et al. 1999. J. Biol. Chem. 274: 9200-9206. PMID: 10092592 2. Tsimokha, A.S., et al. 2006. Tsitologiia. 48: 133-141. PMID: 16737180 3. Kang, M.H., et al. 2007. FEMS Microbiol. Lett. 275: 270-277. PMID: 17725619 4. Tsimokha, A.S., et al. 2007. Tsitologiia. 49: 451-459. PMID: 17802742
Soluble in 100%ethanol, ether, alcohol, and diethyl ether. Insoluble in water.
Store at 4° C
-10° C (lit.)
225° C (lit.)
1.07 g/cm3 at 25° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Diethylmaleate Product Citations
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TsimokhaTsimokha, AS. et al. (PubMed 17802742) reported that treatment of K562 cells with Diethylmaleate led to modification of zeta/alpha5 and iota/alpha6 proteasomal subunits associated with RNAse activity of proteasomes. -SCBT Publication Review
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