Diethylamine NONOate/AMAn intracellular nitric oxide donor

Diethylamine NONOate/AM (CAS 213768-16-2)

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Application: An intracellular nitric oxide donor
CAS Number: 213768-16-2
Purity: ≥95%
Molecular Weight: 205.21
Molecular Formula: C7H15N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diethylamine NONOate/AM is an esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular NO donor. Diethylamine NONOate/AM is shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines (IC50 = 8.3 μM and 53 μM, respectively). The compound also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Diethylamine NONOate/AM exhibits enhanced stability in physiological buffers. It may also be useful for examining temporally and spatially controlled NO availability.


1. Saavedra, J E., et al., 2000. Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: in vitro antileukemic activity. Journal of medicinal chemistry. 43(2): 261-9. PMID: 10649981
2. Kotamraju, S., et al., 2001. Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. The Journal of biological chemistry. 276(20): 17316-23. PMID: 11278975

Usage :
Following reconstitution, aliquot and freeze at -20°C. DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
Physical State :
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
194.80° C (Predicted)
Boiling Point :
~264.62° C at 760 mmHg (Predicted)
IC50 :
leukemia HL-60: IC50 = 8.3 µM (human); U937: IC50 = 53 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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