Dibutyryl-cAMPAn analog of cyclic AMP that stimulates cAMP-dependent protein kinase

Dibutyryl-cAMP (CAS 16980-89-5)

Dibutyryl-cAMP | CAS 16980-89-5 is rated 5.0 out of 5 by 3.
  • y_2019, m_11, d_18, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_201567, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 37ms
  • REVIEWS, PRODUCT
5
3
4
0
3
0
2
0
1
0
Synonym: Bucladesine; Dibutyl cyclic AMP sodium salt; N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
Application: Dibutyryl-cAMP is a cell-permable analog of cyclic AMP (cAMP) that stimulates cAMP-dependent protein kinases.
CAS Number: 16980-89-5
Purity: ≥95%
Molecular Weight: 491.37
Molecular Formula: C18H23N5O8P•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Dibutyryl-cAMP is an analog of cyclic AMP that stimulates PKA (cAMP-dependent protein kinase). The agent has been shown not to effect cAMP levels, gap junction communication or cumulus expansion in cumulus-oocyte complexes. Research shows that dibutyryl-cAMP can stimulate the activity of Na+, K+-ATPase (Na+,K+-pump), bring about morphological differentiation of astrocytes, and block contraction of vas deferens in rat studies. Additionally, other studies show that it can upregulate Nur77 expression through modification of histones during neurite outgrowth in PC-12 cells, and regulate the mRNA levels of Dp71 and dystrophin in rat brain astrocytes.


References

1. Steinberg, R.A., et al. 1981. J. Biol. Chem. 256: 10731-10734. PMID: 6270127

2. Hei, Y.J., et al. 1991. Mol. Pharmacol. 39: 233-238. PMID: 1847496

3. Leszczynski, D., et al. 1994. Am. J. Pathol. 145: 1265-1270. PMID: 7527616

4. Carranza, M.L., et al. 1998. J. Physiol. 511: 235-243. PMID: 9679177

5. Imamura, M., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 6139-6144. PMID: 9600931

6. Bagg, M.A., et al. 2009. Reprod. Fertil. Dev. 21: 796-804. PMID: 19567222

7. Maruoka, H., et al. 2010. J. Biochem. 148: 93-101. PMID: 20375114

Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), DMSO (200 mM), and 96% ethanol (25 mM).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
ES5055500
PubChem CID :
23663967
Merck Index :
14: 1463
MDL Number :
MFCD00005843
EC Number :
241-059-4
SMILES :
CCCC(=O)NC1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Dibutyryl-cAMP  Product Citations

See how others have used Dibutyryl-cAMP. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 44 total

PMID: # 30384126  Lin, H. et al. 2019. Biomaterials. 189: 23-36.

PMID: # 31159811  2019. Part Fibre Toxicol. 16: 22.

PMID: # 31249512  2019. Front Cell Neurosci. 13: 266.

PMID: # 31032369  Radzik, T. et al. 2019. Biomed Res Int. 2019: 9616248.

PMID: # 30383474  Martínez, AL.|Brea, J.|Monroy, X.|Merlos, M.|Burgueño, J.|Loza, MI.| et al. 2019. SLAS Discov. 24: 158-168.

PMID: # 31435904  Hamilton, J. et al. 2019. Mol. Neurobiol.

PMID: # 30792230  Xing, B.|Ma, J.|Jiang, Z.|Feng, Z.|Ling, S.|Szigety, K.|Su, W.|Zhang, L.|Jia, R.|Sun, Y.|Zhang, L.|Kong, X.|Ma, X.|Hua, X.| et al. 2019. J. Cell Biol.

PMID: # 30447390  Sánchez-Iglesias, S. et al. 2019. Neuroscience. 396: 119-137.

PMID: # 30107296  2018. Redox Biol. 19: 62-73.

PMID: # 29512105  Adil, MM. et al. 2018. Curr Protoc Stem Cell Biol. 44: 2D.21.1-2D.21.17.

Citations 1 to 10 of 44 total

Will the powder degrade if stored at room temperature?

Asked by: IsaK
Thank you for your question. Dibutyryl-cAMP (CAS 16980-89-5) should always be stored at -20 °C. The compound will lose its viability if stored at room temperature for a prolonged period of time. Solutions of the product should be prepared fresh before use.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

Do you have any recommendations for stability once the product is in solution? Should freeze/thaw cycles be minimized?

Asked by: two2igm05
Thank you for your question. The solution should be stored at –20 C, protected from light and will be stable for 3-6 months. However, we highly recommend making fresh solution prior to their experiments for quality purposes and freeze/thaw cycles should be minimized. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-18
  • y_2019, m_11, d_18, h_13CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_201567, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 45ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Used in cell culture Used in cell culture. Satisfied with product.
Date published: 2015-10-07
Rated 5 out of 5 by from Used it in our experiments and happy with purchase Used it in our experiments and happy with purchase.
Date published: 2015-06-24
Rated 5 out of 5 by from A decrease in p27 protein expression was A decrease in p27 protein expression was observed by WB in SH-SY5Y cells post treatment with Dibutyryl-cAMP. -SCBT QC
Date published: 2015-03-16
  • y_2019, m_11, d_18, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_201567, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.