DibenzoylmethaneA compound known to inhibit tumorigenesis in mice

Dibenzoylmethane (CAS 120-46-7)

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Application: A compound known to inhibit tumorigenesis in mice
CAS Number: 120-46-7
Molecular Weight: 224.25
Molecular Formula: C15H12O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Dibenzoylmethane is a minor constituent of licorice found to inhibit mammary tumorigenesis, lymphomas, and leukemias in mice.


References

1. Huang, M T., et al., 1998. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis. 19(9): 1697-700. PMID: 9771944
2. Lin, C C., et al., 2001. Inhibition by dietary dibenzoylmethane of mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice. Cancer letters. 168(2): 125-32. PMID: 11403916

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
77-79° C (lit.)
Boiling Point :
219-221° C (lit.) at 18 mmHg
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
K562: IC50 = 30.9 µM (human)
Ki Data :
Acyl coenzyme A:cholesterol acyltransferase: Ki= 3.95 µM (European rabbit); CES1: Ki= 26 µM (human)
pK Values :
pKa: 8.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TZ1930000
PubChem CID :
8433
Merck Index :
14: 3009
MDL Number :
MFCD00003085
EC Number :
204-398-9
Beilstein Registry :
514910
SMILES :
C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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