Diazoxide is a benzothiadiazine derivative which functions as a selective KIR6 (ATP-dependent K+) channel activator and calcium channel blocker. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in smooth muscle. Studies suggest that Diazoxide acts as a peripheral vasodilator. In addition, Diazoxide is used in diabetic studies to increase glucose concentrations in plasma, inhibit the secretion of insulin by β cells of the pancreas, increase the release of catecholamines, and hepatic output of glucose in vitro.
1. Trube, G., et al. 1986. Pflugers Arch. 407: 493-499. PMID: 2431383 2. Quast, U., et al. 1989. J. Pharmacol. Exp. Ther. 250: 261-271. PMID: 2501478 3. Dunne, M.J., et al. 1990. J. Membrane Biol. 114: 53-60. PMID: 2181144 4. Newgreen, D.T., et al. 1990. Br. J. Pharmacol. 100: 605-613. PMID: 2167738
Soluble in ethanol (1:250), DMSO (10 mg/ml), 0.1 M NaOH, methanol (3.2 mg/ml), DMF (50 mg/ml), and alkaline solutions. Insoluble in water.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.