Diacerein CAS: 13739-02-1
MF: C19H12O8
MW: 368.30
A tricyclic psuedo-phenanthrene showing interleukin-1 inhibition.

Diacerein (CAS 13739-02-1)

Diacerein | CAS 13739-02-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 1,8-Diacetoxy-3-carboxyanthraquinone
Application: Diacerein is a tricyclic psuedo-phenanthrene showing interleukin-1 inhibition
CAS Number: 13739-02-1
Purity: ≥98%
Molecular Weight: 368.30
Molecular Formula: C19H12O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diacerein is an IL-1(interleukin-1) inhibitor used for treating osteoarthritis.


References

1. Sharma, A., et al. 2008. J Indian Med Assoc. 106: 54-58. PMID: 18705272
2. Sanfelix-Gimeno, G., et al. 2008. Med Clin. 130: 463-465. PMID: 18405503

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (partly), DMSO, and methanol.
Storage :
Store at room temperature
Melting Point :
217-218° C
Boiling Point :
~631.5° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Female germline-specific tumor suppressor gld-1: IC50 = 7.31 µM (caenorhabditis elegans); Caspase-3: EC5050 = 7.89 µM (human); Heat shock protein HSP90: IC50 = 9.23 µM (human); Caspase-7: EC5050 = 14.80 µM (human); Protein Rev: IC50 >75.41 µM (Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1))
pK Values :
pKa: 3.01 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB8781000
PubChem CID :
Merck Index :
14: 2960
MDL Number :
MFCD00468030
EC Number :
237-310-2
Beilstein Registry :
2184909
SMILES :
CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)OC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Diacerein (CAS 13739-02-1)  Product Citations

See how others have used Diacerein (CAS 13739-02-1). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30272996  Singh, AK. et al. 2018. FASEB J. fj201801513R.

Citations 1 to 1 of 1 total

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a yellow powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16
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Rated 5 out of 5 by from Permuy et al Permuy et al. (PubMed ID 26135886) found that diacerein successfully treated osteoarthritis by reducing swelling and cartilage damage via interkeukin 1 inhibition. -SCBT Publication Review
Date published: 2015-01-27
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