DHEA CAS: 53-43-0
MF: C19H28O2
MW: 288.43
A negative modulator of GABAA receptors.

DHEA (CAS 53-43-0)

DHEA | CAS 53-43-0 is rated 5.0 out of 5 by 1.
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Alternate Names: Dehydro-epi-androsterone; (+)-Dehydroisoandrosterone; 3β-Hydroxy-5-androsten-17-one
Application: DHEA is a negative modulator of GABAA receptors
CAS Number: 53-43-0
Purity: ≥98%
Molecular Weight: 288.43
Molecular Formula: C19H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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DHEA is a major secretory steroidal product of the adrenal gland. DHEA and its sulfated metabolite, DHEA-S, are negative modulators of GABAA receptors. DHEA is an inhibitor of T-type Ca++ CP α 1G, T-type Ca++ CP α 1H and T-type Ca++ CP α 1I and an activator of Sigma Receptor, PXR and Estrogen Receptor.


References

Hansen, S.L., et al. 1999. Mol. Pharmacol. 55, 489. Imamura, M., and Prasad, C. 1998. Biochem. Biophys. Res. Commun. 243, 771. Majewska, M.D., et al. 1990. Brain Res. 526, 143.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol, benzene, and ether.
Storage :
Store at room temperature
Melting Point :
149.05-151.05° C
Boiling Point :
~426.70° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D 12.5°±1°, c = 2 in ethanol
IC50 :
J774.A1: IC50 = 141 nM (mouse)
Ki Data :
Glucose-6-phosphate 1-dehydrogenase: Ki= 1100 nM (Trypanosoma brucei)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
WGK Germany :
2
RTECS :
BV8396000
Transport :
Not available for sale outside of the United States.
PubChem CID :
Merck Index :
14: 2871
MDL Number :
MFCD00003613
EC Number :
200-175-5
Beilstein Registry :
2058110

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DHEA (CAS 53-43-0)  Product Citations

See how others have used DHEA (CAS 53-43-0). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29958542  Furat Rencber, S.|Kurnaz Ozbek, S.|Eraldemır, C.|Sezer, Z.|Kum, T.|Ceylan, S.|Guzel, E.| et al. 2018. J Ovarian Res. 11: 55.

PMID: # 29397924  Fertil Steril. 728-734.e2.

PMID: # 32994975  Food Sci Nutr. 5149-5159.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Ghisleni et al Ghisleni et al. (PubMed ID 26356576) found that DHEA, a negative modulator of GABA receptors, was responsible for sex differences in perfusion, with women showing more global and regional perfusion than men. -SCBT Publication Review
Date published: 2015-01-08
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