DexmedetomidineCAS: 113775-47-6, MF: C13H16N2, MW: 200.28

Dexmedetomidine (CAS 113775-47-6)

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CAS Number: 113775-47-6
Purity: 98%
Molecular Weight: 200.28
Molecular Formula: C13H16N2
* Refer to Certificate of Analysis for lot specific data (including water content).
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A sedative, analgestic, α2-Adrenergic agonist and (+)-isomer of medetomidine.


References

Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994), Jalonen, J., et al.: Anesthesiology, 86, 331 (1997), Talke, P., et al.: Anesth. Analg., 85, 1136 (1997), Bhana, N., et al.: Drugs, 59, 263 (2000),

Physical State :
Solid
Solubility :
Soluble in chloroform, and methanol.
Storage :
Store at -20° C
Melting Point :
146-149° C
Boiling Point :
381.87° C at 760 mmHg (Predicted)
Density :
1.05 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Alpha-2a adrenergic receptor: EC5050 = 1.5 nM (human)
Ki Data :
Alpha-2b adrenergic receptor: Ki= 0.015 nM (Rattus norvegicus); Alpha-2c adrenergic receptor: Ki= 0.015 nM (Rattus norvegicus); Alpha-2a adrenergic receptor: Ki= 0.015 nM (Rattus norvegicus); Alpha-1d adrenergic receptor: Ki= 0.015 nM (human); Adrenergic receptor alpha-1: Ki= 5 nM (Rattus norvegicus)
pK Values :
pKb: 6.65
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NI5156400
PubChem CID :
5311068
SMILES :
CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C

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Certificate of Analysis

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Dexmedetomidine  Product Citations

See how others have used Dexmedetomidine. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27929541  Nizari, S. et al. 2016. Cell Death Dis. 7: e2514.

PMID: # 26435028  Kawamoto, S. et al. 2015. Eur. J. Pharmacol. 766: 122-8.

PMID: # 24803295  Xiang, H. et al. 2014. Inflammation. 37: 1763-70.

PMID: # 22683080  Peng, M. et al. 2013. J. Surg. Res. 179: e219-25.

PMID: # 22150679  Zhang, F. et al. 2012. J. Pharm. Pharmacol. 64: 120-7.

Citations 1 to 5 of 5 total
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