Dexamethasone AcetateA glucocorticoid

Dexamethasone Acetate (CAS 1177-87-3)

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Application: A glucocorticoid
CAS Number: 1177-87-3
Purity: ≥99%
Molecular Weight: 434.5
Molecular Formula: C24H31FO6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible mode of action of the anti-inflammatory properties has been documented by Dexamethasone Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured human mast cells. The compound also displays anti mitotic activity against chemically transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.


References

1. Fagot, D., et al. 1991. Endocrinology. 129: 1033-1041. PMID: 1906802
2. Roberts, C.P., et al. 1996. Am. J. Obstet. Gynecol. 175: 248-257. PMID: 8765239
3. Inamura, H., et al. 2001. Allergy. 56: 672-678. PMID: 11421927
4. Clark, J.A., et al. 2008. Mol. Psychiatry. 13: 498-506. PMID: 17622221
5. Wang, M.T., et al. 2010. Int J. Nanomedicine. 5: 487-497. PMID: 20957171

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in alcohol, DMSO (87 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (20 mg/ml at 25° C), and methanol.
Storage :
Store at 4° C
Melting Point :
225° C (dec.)
Boiling Point :
579.39° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α20/D 85°±3°, c = 1 in Dioxane
pK Values :
pKa: 12.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TU4050000
PubChem CID :
3680
Merck Index :
14: 2943
MDL Number :
MFCD00027407
EC Number :
214-646-8
Beilstein Registry :
2342608
SMILES :
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C

Download SDS (MSDS)

Certificate of Analysis

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