Desipramine hydrochlorideAn inhibitor of norepinephrine, serotonin, and dopamine transporters

Desipramine hydrochloride (CAS 58-28-6)

Desipramine hydrochloride | CAS 58-28-6 is rated 5.0 out of 5 by 2.
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Synonym: N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
Application: An inhibitor of norepinephrine, serotonin, and dopamine transporters
CAS Number: 58-28-6
Purity: ≥98%
Molecular Weight: 302.84
Molecular Formula: C18H22N2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Desipramine HCl is a selective inhibitor of noradrenaline the transporters norepinephrine transporter (SLC6A2 or NET; Ki = 4 nM), serotonin transporter (ST or SERT; Ki = 61 nM), and dopamine transporter (DAT; Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display antiinflammatory activity in a rat colitis model.


References

1. Checkley, S.A., et al. 1981. Br J Psychiatry. 138: 248-251. PMID: 6268238
2. Potter, W.Z., et al. 1981. Psychopharmacol Bull. 17: 26-29. PMID: 6453356
3. Zhu, M.Y., et al. 1998. J. Neurochem. 70: 1547-1555. PMID: 9523572
4. Okugawa, G., et al. 1999. J. Neuroendocrinol. 11: 887-895. PMID: 10520140
5. Smith, N.C. and Levi, R. 1999. J. Pharmacol. Exp. Ther. 291: 456-463. PMID: 10525059
6. Zhao, Z., et al. 2008. Neuropsychopharmacology. 33: 3190-3200. PMID: 18418364
7. Bachis, A., et al. 2008. Neurosci. Lett. 442: 104-108. PMID: 18621098

Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), alcohol, and methanol.
Storage :
Store at room temperature
Melting Point :
214-218° C
IC50 :
Serotonin transporter: IC50 = 2.5 nM
Ki Data :
SLC6A2 : Ki= 4 nM; ST: Ki= 61 nM; DAT: Ki= 78720 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HO0525000
PubChem CID :
65327
Merck Index :
14: 2920
MDL Number :
MFCD00058108
EC Number :
200-373-1
SMILES :
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

Download SDS (MSDS)

Certificate of Analysis

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Desipramine hydrochloride  Product Citations

See how others have used Desipramine hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28587819  Benham, RS. et al. 2017. Behav. Brain Res. 332: 172-179.

PMID: # 27080063  Reimets, R. et al. 2016. Behavioural brain research. 308: 53-63.

PMID: # 26100518  Lin, PH. et al. 2015. J. Biomed. Sci. 22: 44.

Citations 1 to 3 of 3 total

Hi, Desipramine is powder or tablet? Thank you

Asked by: david38120
Thank you for the question. The product is sold as solid, it is soluble in water (>25 mg/ml), alcohol, and methanol. Please note that our biochemicals are sold for research or laboratory use only and are not to be administered to humans or used for medical diagnostics.
Answered by: Technical Support Europe
Date published: 2018-01-11
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Rated 5 out of 5 by from Excellent It did works perfectly. I got excellent results. Perfect.
Date published: 2017-01-25
Rated 5 out of 5 by from Bachis et al Bachis et al. (PubMed ID 18621098) showed that Desipramine hydrochloride, a common antidepressant, reversed pro-apoptotic effects of chronic unpredictable mild stress in rat neurons. -SCBT Publication Review
Date published: 2015-02-23
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