DerquantelA semi-synthetic paraherquamide analog and potent nematocide

Derquantel (CAS 187865-22-1)

Derquantel | CAS 187865-22-1 is rated 5.0 out of 5 by 1.
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Synonym: 2-Deoxoparaherquamide
Application: A semi-synthetic paraherquamide analog and potent nematocide
CAS Number: 187865-22-1
Molecular Weight: 479.61
Molecular Formula: C28H37N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of AChR (nicotinic acetylcholine receptors) acting as an antagonist of acetylcholine.

Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, DMSO, DMF, and water (poorly).
Storage :
Store at -20° C
Boiling Point :
~641.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKb: 7.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25154194
MDL Number :
MFCD13195549
SMILES :
C[C@]1(CCN2[C@]13C[C@@H]4[C@](C2)(C[C@]5(C4(C)C)CNC6=C5C=CC7=C6OC=CC(O7)(C)C)N(C3=O)C)O

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Certificate of Analysis

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Rated 5 out of 5 by from Li et al Li et al. (PubMed ID 26199859) found that the anthelmintic, derquantel, functioned by targeting neuromuscular junction acetylcholine receptors. -SCBT Publication Review
Date published: 2015-07-20
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