Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of AChR (nicotinic acetylcholine receptors) acting as an antagonist of acetylcholine.
Soluble in ethanol, methanol, DMSO, DMF, and water (poorly).
Store at -20° C
~641.3° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.67 (Predicted)
pKb: 7.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Li et alLi et al. (PubMed ID 26199859) found that the anthelmintic, derquantel, functioned by targeting neuromuscular junction acetylcholine receptors. -SCBT Publication Review
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