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Dequalinium chloride is a selective blocker of apamin-sensitive K+ channels and inhibitor of XIAP (X-linked inhibitor of apoptosis protein). The compound has induced apoptosis in leukemia B4 cells through disturbance of mitochondrial function, oxidative stress, and downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways.
Rotenberg, S.A. and Sun, X.G. J. Biol. Chem. 273, 2390, (1998)
See how others have used Dequalinium chloride. Click on the entry to view the PubMed entry .
PMID: # 27826078 Landa-Juárez, AY. et al. 2016. Eur. J. Pharmacol. 793: 95-100.
PMID: # 29704200 Mol. Neurobiol. 56: 367-377.
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