Deoxymannojirimycin HCl is a mannose analog that inhibits mammalian MAN1A2 (Golgi-alpha-mannosidase I) at the active site. Known to block the biosynthesis of complex oligosaccharides. However, it does not block endoplasmic reticulum alpha-mannosidase. Observed to induce disorganization of the extracellular matrix fibronectin assembly. Also, deoxymannojirimycin treated in hepatocarcinoma H7721 cells resulted in ER stress and apoptosis.
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See how others have used Deoxymannojirimycin hydrochloride (CAS 84444-90-6). Click on the entry to view the PubMed entry .
PMID: # 20209334 Mora-Montes, HM. et al. 2010. Mem. Inst. Oswaldo Cruz. 105: 79-85.
PMID: # 3159432 Fuhrmann, U. et al. 1985. Biochim. Biophys. Acta. 825: 95-110.
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