Deoxymannojirimycin HCl is a mannose analog that inhibits mammalian MAN1A2 (Golgi-alpha-mannosidase I) at the active site. Known to block the biosynthesis of complex oligosaccharides. However, it does not block endoplasmic reticulum alpha-mannosidase. Observed to induce disorganization of the extracellular matrix fibronectin assembly. Also, deoxymannojirimycin treated in hepatocarcinoma H7721 cells resulted in ER stress and apoptosis.
1. Gross, V., et al. 1985. Eur. J. Biochem. 150: 41-46. PMID: 3160588
2. Bischoff, J., et al. 1986. J. Biol. Chem. 261: 4766-4774. PMID: 2937779
3. Suzuki, S.S., et al. 1993. J. Cell. Biochem. 51: 181-189. PMID: 8440752
4. Lu, Y., et al. 2006. Biochem. Biophys. Res. Commun. 344: 221-225. PMID: 16615997
See how others have used Deoxymannojirimycin hydrochloride. Click on the entry to view the PubMed entry .
PMID: # 20209334 Mora-Montes, HM. et al. 2010. Mem. Inst. Oswaldo Cruz. 105: 79-85.
PMID: # 3159432 Fuhrmann, U. et al. 1985. Biochim. Biophys. Acta. 825: 95-110.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.