Deoxy VenlafaxineA useful impurity of the serotonin and norepinephrine reuptake inhibitor Venlafaxine

Deoxy Venlafaxine (CAS 1076199-92-2)

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Synonym: Venlafaxine EP Impurity G
Application: A useful impurity of the serotonin and norepinephrine reuptake inhibitor Venlafaxine
CAS Number: 1076199-92-2
Molecular Weight: 261.40
Molecular Formula: C17H27NO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Deoxy Venlafaxine is an impurity of Venlafaxine (sc-201102). Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake. In vitro studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.


References

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333
3. Bymaster, F.P., et al. 2001. Neuropsychopharmacology. 25: 871-880. PMID: 11750180
4. Stahl, S.M., et al. 2005. CNS Spectr. 10: 732-747. PMID: 16142213
5. Shams, M.E., et al. 2006. J Clin Pharm Ther. 31: 493-502. PMID: 16958828
6. Blier, P., et al. 2007. Int. J. Neuropsychopharmacol. 10: 41-50. PMID: 16690005
7. Berrocoso, E. and Mico, J.A. 2007. J. Pharmacol. Exp. Ther. 322: 101-107. PMID: 17431134

Physical State :
Solid
Solubility :
Soluble in chloroform, methanol, DMSO, and DMF.
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
15345869
SMILES :
CN(C)CC(C1CCCCC1)C2=CC=C(C=C2)OC

Download SDS (MSDS)

Certificate of Analysis

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