DenbufyllineA xanthine derivative PDE IV inhibitor

Denbufylline (CAS 57076-71-8)

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Application: A xanthine derivative PDE IV inhibitor
CAS Number: 57076-71-8
Molecular Weight: 320.4
Molecular Formula: C16H24N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Denbufylline is a selective xanthine derivative that inhibits PDE IV and has bronchodilatory properties. Shown to exhibit negative inotropic effects by acting on verapamil-sensitive sites of Ca2+ channels in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity.


References

1. Nicholson, C.D., et al. 1989. Br. J. Pharmacol. 97: 889-897. PMID: 2474352
2. Cortijo, J., et al. 1993. Br. J. Pharmacol. 108: 562-568. PMID: 8383567
3. Sanae, F., et al. 1996. J. Pharmacol. Exp. Ther. 277: 54-60. PMID: 8613965
4. Kumari, M., et al. 1997. Br. J. Pharmacol. 121: 459-468. PMID: 9179387

Physical State :
Solid
Solubility :
Soluble in DMSO, and MeOH.
Storage :
Store at 4° C
Melting Point :
98-100° C
Boiling Point :
514.81° C at 760 mmHg (Predicted)
Density :
1.24 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Phosphodiesterase 4A: IC50 = 0.17 nM (human)
Ki Data :
phosphodiesterase IV : Ki= ~ 1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2984
SMILES :
CCCCN1C2=C(C(=O)N(C1=O)CCCC)N(C=N2)CC(=O)C

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Certificate of Analysis

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