Delta12-PGJ2 (Delta12-Prostaglandin J2)A decomposition product of PGD2 showing potent antiviral and anti-proliferative activity

Δ12-PGJ2 (Δ12-Prostaglandin J2) (CAS 87893-54-7)

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Application: A decomposition product of PGD2 showing potent antiviral and anti-proliferative activity
CAS Number: 87893-54-7
Purity: 98%
Molecular Weight: 334.5
Molecular Formula: C20H30O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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δ12-PGJ2 (δ12-Prostaglandin J2) is a decomposition product of PGD2 (sc-201221) that has shown potent antiviral and anit-proliferative activity. This compound has also been shown to induce apoptosis, and to inhibit phosphoinositide turnover. Conjugation with glutathione (sc-29094) is thought to enhance the cytotoxicity of δ12-PGJ2. Similar to other prostaglandins, it is often difficult to distinguish between biological activities derived directly from 'parent' molecules and those derived from metabolites thereof.


References

1. Diczfalusy, U., et al. 1977. FEBS Lett. 84: 271-274. PMID: 598509
2. Narumiya, S., et al. 1986. J. Pharmacol. Exp. Ther. 239: 500-505. PMID: 3772804
3. Atsmon, J., et al. 1990. Cancer Res. 50: 1879-1885. PMID: 2306739
4. Nakahata, N., et al. 1990. Prostaglandins. 40: 405-416. PMID: 2177901
5. Kim, I.K., et al. 1993. FEBS Lett. 321: 209-214. PMID: 8477853

Appearance :
Viscous oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (>25 mg/ml), DMSO (>25 mg/ml), and acetone.
Storage :
Store at -80° C
Refractive Index :
n20D 1.56
IC50 :
growth of cultured L1210: IC50 = 0.7 µg/ml; mPGES1: IC50 = 64 µM
pK Values :
pKa: 4.75
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5280885
SMILES :
CCCCCC(CC=C1C(C=CC1=O)CC=CCCCC(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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