Delanzomib, free baseA proteasome inhibitor

Delanzomib, free base (CAS 847499-27-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 53ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acid
Application: A proteasome inhibitor
CAS Number: 847499-27-8
Molecular Weight: 413.28
Molecular Formula: C21H28BN3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Delanzomib is a proteasome inhibitor. Delanzomib inhibits chymotrypsin-like proteasome activity with an IC50 of 3.8 nM. Delanzomib blocks the growth of representative human solid and hematological tumor cell lines with IC50 values of <35 nM. Delanzomib also inhibits endothelial cell survival, proliferation, and morphogenesis.

Physical State :
Solid
Solubility :
Soluble in DMSO (83 mg/ml at 25 °C), chloroform, methanol, ethanol (83 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
185-190 °C (dec.)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
20S Proteasome β5: IC50 = 3.5 nM (human); Chymotrypsin-like activity of human erythrocyte 20S proteasome: IC50 = 3.8 nM; cathepsin G: IC50 = 13.7 nM (human); Caspase-like activity of proteasome: IC50 = 70 nM; α chymotrypsin: IC50 = 1.5 µM (bovine)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24800541
MDL Number :
MFCD18251439
SMILES :
B([C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 66ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 52ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.