Delanzomib is a proteasome inhibitor. Delanzomib inhibits chymotrypsin-like proteasome activity with an IC50 of 3.8 nM. Delanzomib blocks the growth of representative human solid and hematological tumor cell lines with IC50 values of <35 nM. Delanzomib also inhibits endothelial cell survival, proliferation, and morphogenesis.
Soluble in DMSO (83 mg/ml at 25 °C), chloroform, methanol, ethanol (83 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
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