DeguelinAn inhibitor of Cox-2

Deguelin (CAS 522-17-8)

Deguelin | CAS 522-17-8 is rated 5.0 out of 5 by 1.
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Synonym: (-)-cis-Deguelin
Application: An inhibitor of Cox-2
CAS Number: 522-17-8
Purity: ≥95%
Molecular Weight: 394.4
Molecular Formula: C23H22O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Deguelin is a natural product that displays profound antiproliferative activity. Deguelin induces apoptosis, mediated through AKT/PKB signaling pathways in malignant and premaligant human bronchial epithelia (HBE) cells, with only minimal effects on normal HBE cells. Deguelin inhibits AKT by both PI 3-kinase dependent and PI 3-kinase independent pathways. Deguelin has displayed anti-tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in tumor models. Deguelin has also been shown to inhibit Cox-2 expression.


References

1. Chun, K.H., et al. 2003. J. Natl. Cancer Inst. 95: 291-302. PMID: 12591985
2. Lee, H.Y., 2004. Biochem. Pharmacol. 68: 1119-1124. PMID: 15313408
3. Lee, H.Y., et al. 2004. Clin. Cancer Res. 10: 1074-1079. PMID: 14871987
4. Hu, J., et al. 2010. Int. J. Cancer. 127: 2455-2466. PMID: 20162567

Physical State :
Solid
Solubility :
Soluble in DMSO(25 mg/mL) and ethanol(25 mg/mL)
Storage :
Store at 4° C
Melting Point :
85-87° C
Boiling Point :
560.1° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
107935
SMILES :
CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C

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Certificate of Analysis

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Deguelin  Product Citations

See how others have used Deguelin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28456666  Matsushima-Nishiwaki, R. et al. 2017. Biochim. Biophys. Acta. 1863: 1629-1639.

Citations 1 to 1 of 1 total

i want to ask about the solubility of deguelin

Asked by: ambreen
Thank you for your question. Deguelin is soluble in DMSO (25 mg/mL) and ethanol (25 mg/mL).
Answered by: Technical Support
Date published: 2017-09-27
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Rated 5 out of 5 by from Hu et al Hu et al. (PubMed ID 20162567) found that the tumor inhibitor, deguelin, suppressed tumor lymphangiogenesis and lymphatic metastasis via downregulation of VEGF-D in vascular endothelial cells. -SCBT Publication Review
Date published: 2015-01-22
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