Debromohymenialdisine CAS: 75593-17-8
MF: C11H11N5O2
MW: 245.2
A G2 DNA damage checkpoint inhibitor.

Debromohymenialdisine (CAS 75593-17-8)

Debromohymenialdisine | CAS 75593-17-8 is rated 5.0 out of 5 by 1.
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Alternate Names: DBH
Application: Debromohymenialdisine is a G2 DNA damage checkpoint inhibitor
CAS Number: 75593-17-8
Purity: ≥95% (HPLC)
Molecular Weight: 245.2
Molecular Formula: C11H11N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Debromohymenialdisine is an inhibitor of G2 DNA damage checkpoint (IC50 = 8 μM) and check point kinases 1 (Chk1) and 2 (Chk2) (IC50 = 3 μM and IC50 = 3.5 μM, respectively). Differing from many other checkpoint inhibitors, Debromohymenialdisine does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Debromohymenialdisine also inhibits MAP kinase kinase 1 (MEK-1) (IC50 = 881 nM) but is not as potent as 10Z-hymenialdisine (IC50 = 6 nM).


References

1. Curman, D., et al. 2001. J. Biol. Chem. 276: 17914-17919. PMID: 11279124
2. Tasdemir, D. , et al. 2002. J. Med. Chem. 45: 529-532. PMID: 11784156
3. Kawabe, T. 2004. Mol. Cancer Ther. 3: 513-519. PMID: 15078995

Physical State :
Solid
Derived From :
Axinella carteri.
Solubility :
Soluble in DMSO, methanol, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
>250° C (dec.)
Boiling Point :
599.75° C (Predicted)
Density :
1.82 g/cm3 at 20° C
Refractive Index :
n20D 1.88 (Predicted)
IC50 :
Chk2: IC50 = 183 nM (human); Chk1: IC50 = 330 nM (human); ERK 2: IC50 = 824 nM (human); MEK-1: IC50 = 881 nM
pK Values :
pKa: 10.22 (Predicted), pKb: 2.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD04037016
SMILES :
C\\1CNC(=O)C2=C(/C1=C/3\\C(=O)N=C(N3)N)C=CN2

Download SDS (MSDS)

Certificate of Analysis

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Debromohymenialdisine (CAS 75593-17-8)  Product Citations

See how others have used Debromohymenialdisine (CAS 75593-17-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23125222  Blakemore, LM. et al. 2013. Carcinogenesis. 34: 351-60.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Kawabe (PubMed ID 15078995) used decromohymenialdisine Kawabe (PubMed ID 15078995) used decromohymenialdisine to inhibit CHK1 and CHK2 in cancer cells. -SCBT Publication Review
Date published: 2015-02-08
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