Debrisoquin sulfate CAS: 581-88-4
MF: C10H13N3•1/2H2SO4
MW: 224.3
An antihypertensive that is an useful indicator for cytochrome P-450 polymorphism.

Debrisoquin sulfate (CAS 581-88-4)

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Alternate Names: Isocaramidine sulfate; Ro 5-3307
Application: Debrisoquin sulfate is an antihypertensive that is an useful indicator for cytochrome P-450 polymorphism
CAS Number: 581-88-4
Molecular Weight: 224.3
Molecular Formula: C10H13N31/2H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Debrisoquin sulfate is an antihypertensive. It is metabolized to 4-hydroxydebrisoquin by debrisoquin 4-hydroxylase. Debrisoquin sulfate is useful indicator for cytochrome P-450 polymorphism. This can also be used to probe for CYP2D6 activity as well as phenotype individuals as extensive or poor metabolizers. Debrisoquin sulfate is a substrate of CYP2D6.


References

1. Medina, M.A., et al. 1969. Biochem. Pharmacol. 18: 891-901. PMID: 5788526
2. Gonzalez, F.J., et al. 1987. DNA. 6: 149-161. PMID: 3582092
3. Guengerich, F.P. 1989. Trends Pharmacol. Sci. 10: 107-109. PMID: 2688217
4. Cerqueira, P.M., et al. 2000. J. Chromatogr. B Biomed. Sci. Appl. 749: 153-161. PMID: 11145052

Physical State :
Solid
Solubility :
Soluble in water (29mg/ml)
Storage :
Store at room temperature
Melting Point :
268-270° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NW7010000
PubChem CID :
Merck Index :
14: 2844
MDL Number :
MFCD00153791
EC Number :
209-472-4
SMILES :
C1CN(CC2=CC=CC=C21)C(=N)N.C1CN(CC2=CC=CC=C21)C(=N)N.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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