Molecular structure of Debrisoquin sulfate, CAS Number: 581-88-4
Debrisoquin sulfate (CAS 581-88-4)
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Alternate Names:
Isocaramidine sulfate; Ro 5-3307
Application:
Debrisoquin sulfate is an antihypertensive that is an useful indicator for cytochrome P-450 polymorphism
CAS Number:
581-88-4
Molecular Weight:
224.3
Molecular Formula:
C10H13N3•1/2H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Debrisoquin sulfate is metabolized to 4-hydroxydebrisoquin by debrisoquin 4-hydroxylase. Debrisoquin sulfate is useful indicator for cytochrome P-450 polymorphism. This can also be used to probe for CYP2D6 activity as well as phenotype individuals as extensive or poor metabolizers. Debrisoquin sulfate is a substrate of CYP2D6. Debrisoquin sulfate works by blocking the action of certain receptors in the body called alpha-1 adrenergic receptors. These receptors are found in various tissues, including the smooth muscles of blood vessels.
Debrisoquin sulfate (CAS 581-88-4) References
- Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers. | Cerqueira, PM., et al. 2000. J Chromatogr B Biomed Sci Appl. 749: 153-61. PMID: 11145052
- CLINICAL PHARMACOLOGICAL STUDIES WITH DEBRISOQUIN SULFATE, A NEW ANTIHYPERTENSIVE AGENT. | ABRAMS, WB., et al. 1964. J New Drugs. 4: 268-83. PMID: 14218621
- Effect of ceruletide on plasma monoamine metabolites in the rabbit. | Wakata, N., et al. 1991. J Neurol Sci. 103: 97-100. PMID: 1713954
- The effect of debrisoquin on MAO A and MAO B activities. | Javors, MA., et al. 1989. Life Sci. 45: 2359-64. PMID: 2601584
- Polymorphism of cytochrome P-450 in humans. | Guengerich, FP. 1989. Trends Pharmacol Sci. 10: 107-9. PMID: 2688217
- Multiple pathways of propranolol's metabolism are inhibited by debrisoquin. | Anthony, L., et al. 1989. Clin Pharmacol Ther. 46: 297-300. PMID: 2776392
- Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities. | Ward, SA., et al. 1989. Clin Pharmacol Ther. 45: 72-9. PMID: 2910639
- The degree of PCB chlorination determines whether the rise in urinary homovanillic acid production in rats is peripheral or central in origin. | Seegal, RF., et al. 1988. Toxicol Appl Pharmacol. 96: 560-4. PMID: 3144778
- Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. | Gonzalez, FJ., et al. 1987. DNA. 6: 149-61. PMID: 3582092
- Increased catecholamine output in the hypertensive fawn-hooded rat. | Magro, AM., et al. 1986. Lab Anim Sci. 36: 646-9. PMID: 3821054
- Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig. | Edwards, DJ., et al. 1985. Biochem Pharmacol. 34: 2911-6. PMID: 3896245
- On the physiological disposition and possible mechanism of the antihypertensive action of debrisoquin. | Medina, MA., et al. 1969. Biochem Pharmacol. 18: 891-901. PMID: 5788526
- Studies on the central or peripheral origin of free and sulfated 3,4-dihydroxyphenylacetic acid in rat plasma. | Boudet, C., et al. 1984. Eur J Pharmacol. 103: 295-301. PMID: 6149138
- The cardiovascular effects of the antihypertensive drug debrisoquin: A contribution to the pharmacology of chronic treatment. II. Eight-week administration to dogs. | Gerold, M., et al. 1978. J Pharmacol Exp Ther. 206: 535-44. PMID: 702320
Substrate of:
CYP2D6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Debrisoquin sulfate, 50 mg | sc-200725 | 50 mg | $178.00 | |||
Debrisoquin sulfate, 250 mg | sc-200725A | 250 mg | $592.00 |