DD1 CAS: 187585-11-1
MF: C5H9BrN2O2
MW: 209.04
An NO donor and guanylate cyclase activator.

DD1 (CAS 187585-11-1)

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Alternate Names: 3-Bromo-3,4,4-trimethyl-3,4-dihydrodiazete 1,2-dioxide
Application: DD1 is an NO donor and guanylate cyclase activator
CAS Number: 187585-11-1
Molecular Weight: 209.04
Molecular Formula: C5H9BrN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

DD1 is a cell permeable thiol-induced nitric oxide (NO) donor with strong vasodilating effects. DD1 also acts as a guanylate cyclase activator.


References

1. Utepbergenov, D I., et al., 1995. Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2-dioxides and their vasodilatory properties in vitro and in vivo. Biochemical and biophysical research communications. 214(3): 1023-32. PMID: 7575505
2. Kirilyuk, I A., et al., 1998. Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides. Journal of medicinal chemistry. 41(7): 1027-33. PMID: 9544202
3. Dikalov, Sergey., et al., 2002. Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase. The Journal of biological chemistry. 277(28): 25480-5. PMID: 11983711
4. Sagoo, Pervinder., et al., 2004. Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide. Investigative ophthalmology & visual science. 45(11): 3964-73. PMID: 15505043

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
382423
SMILES :
CC1(C([N+](=O)N1[O-])(C)Br)C

Download SDS (MSDS)

Certificate of Analysis

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