DavercinA high potency semi-synthetic erythromycin

Davercin (CAS 55224-05-0)

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Synonym: erythromycin A cyclic 11,12-carbonate
Application: A high potency semi-synthetic erythromycin
CAS Number: 55224-05-0
Molecular Weight: 759.92
Molecular Formula: C38H65NO14
* Refer to Certificate of Analysis for lot specific data (including water content).
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Davercin is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, DMF, DMSO. Limited water solubility.
Storage :
Store at -20° C
Boiling Point :
859.75 °C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
KF46700000
PubChem CID :
10033072
SMILES :
CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)O)C)C)OC(=O)O2)C

Download SDS (MSDS)

Certificate of Analysis

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