Daunorubicin hydrochloride is a DNA intercalating anthracylcine natural product isolated from Streptomyces peucetius. Upon intercalation, Daunorubicin forms stable complexes with the DNA backbone, inhibiting normal functioning of the double helix and the proteins that interact with it. Daunorubicin is nearly identical in structure to Doxorubicin (sc-200923), with Doxorubicin containing a pendant hydroxyl group on the exocyclic ketone. The action of Daunorubicin has been correlated to efficacy in suppressing the proliferation of certain acute leukemias. Daunorubicin hydrochloride is an inhibitor of Topo I and Topo II and an activator of LASS.
1. Weiss, R.B. 1992. Semin. Oncol. 19: 670-686. PMID: 1462166 2. Taatjes, D.J., et al. 1996. J. Med. Chem. 39: 4135-4138. PMID: 8863788 3. Trieb, M., et al. 2004. J. Biomol. Struct. Dyn. 21: 713-724. PMID: 14769064
Soluble in water (≥113), methanol, ethanol (≥10), and DMSO (≥72 mg/mL).
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ZhangZhang, X. et al. (PubMed 26051726) reported that the combination of arsenic trioxide and Daunorubicin could promote acute promyelocytic leukemia (APL) and NB4 cell apoptosis effectively without aggravating blood coagulation disorders, which might improve coagulation function of APL by inhibiting coagulation and hyperfibrinolysis through reducing expression of tissue factor and annexin II. -SCBT Publication Review
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