DasatinibA chemical directly targets wild-type and mutant c-Abl kinase domains

Dasatinib (CAS 302962-49-8)

Dasatinib | CAS 302962-49-8 is rated 5.0 out of 5 by 1.
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Synonym: Sprycel
Application: A chemical directly targets wild-type and mutant c-Abl kinase domains
CAS Number: 302962-49-8
Purity: ≥99%
Molecular Weight: 488.01
Molecular Formula: C22H26ClN7O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (~325-fold) increased potency relative to imatinib. Dasatinib is a potent wild-type and mutant c-Abl inhibitor, except T315I. Dasatinib directly targets wild-type and mutant c-Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. Dasatinib treatment inhibits SRC signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells. Dasatinib (anhydrous) is an inhibitor of c-Src.

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/mL), ethanol (very poorly ), and water (very poorly ).
Storage :
Store at -20° C
Melting Point :
272-274° C
IC50 :
wild type Abl: IC50 = 0.6 nM; Src: IC50 = 0.8 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3062316
MDL Number :
MFCD11046566
SMILES :
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C

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Dasatinib  Product Citations

See how others have used Dasatinib. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 30321617  Tsai, CC.|Chou, YT.|Fu, HW.| et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 486-503.

PMID: # 30976201  Stock, K.|Borrink, R.|Mikesch, JH.|Hansmeier, A.|Rehkämper, J.|Trautmann, M.|Wardelmann, E.|Hartmann, W.|Sperveslage, J.|Steinestel, K.| et al. 2019. Cancer Cell Int. 19: 77.

PMID: # 29666146  Tamai, TK. et al. 2018. EMBO Mol Med. 10:

PMID: # 28286026  Pak, JH. et al. 2017. Mol. Biochem. Parasitol. 214: 1-9.

PMID: # 28336715  Kalxdorf, M. et al. 2017. Mol. Cell Proteomics. 16: 770-785.

PMID: # 28855374  Olvera, M. et al. 2017. Mol. Biol. Cell. 14: 1036-42.

PMID: # 27576506  Mahendrarajah, N. et al. 2016. Journal of cancer research and clinical oncology. 142: 2263-73.

PMID: # 26084847  Sievers, E. et al. 2015. International journal of cancer. 137: 2578-88.

PMID: # 26181649  Tobío, A. et al. 2015. Immunopharmacol Immunotoxicol. 37: 380-7.

PMID: # 26607773  Yilmaz, O. et al. 2015. Growth Factors. 33: 366-75.

Citations 1 to 10 of 22 total

Dose it can use in animal expriment? how much dose (for example:rat ) ?

Asked by: Shisanyue
Thank you for your question. Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds in animals.
Answered by: Technical Support
Date published: 2017-09-11

Dasatinib (CAS 302962-49-8) 25mg

Asked by: Harish lab
Thank you for your inquiry. I am not sure what you are asking. For information regarding our chemical products, please contact our Customer Service group. You can reach them by phone at 800-457-3801, option 1, or by email at customercare@scbt.com or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-08-14
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Rated 5 out of 5 by from Works great Works great, we purchase it regularly.
Date published: 2015-04-09
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