DAR-4M AMA cell-permeable photo-stable nitric oxide fluorescent indicator

DAR-4M AM

DAR-4M AM is rated 5.0 out of 5 by 1.
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Synonym: Diaminorhodamine-4M AM
Application: A cell-permeable photo-stable nitric oxide fluorescent indicator
Molecular Weight: 630.47
Molecular Formula: C28H31IN4O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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DAR-4M AM is a cell-permeable, photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM. Intracellularly releases DAR-4M by the action of esterases. Reacts with NO, in the presence of oxygen, resulting in a triazolo-rhodamine analog (DAR-4M T) that exhibits about 840-fold greater fluorescence quantum efficiency. The fluorescence intensity of DAR-4M AM is not dependent on pH.


References

1. Kojima, H., et al. 2001. Anal. Chem. 73: 1967-1973. PMID: 11354477

Formulation :
5mM in DMSO
Physical State :
Liquid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Melting Point :
18.45° C
Density :
1.1 g/mL at 20° C
Fluoresence :
λex ~560 nm, λem ~575 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
10484141
MDL Number :
MFCD11045857
SMILES :
CC(=O)OCOC(=O)C1=C(C=CC(=C1N)NC)C2=C3C=CC(=[N+](C)C)C=C3OC4=C2C=CC(=C4)N(C)C.[I-]

Download SDS (MSDS)

Certificate of Analysis

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DAR-4M AM  Product Citations

See how others have used DAR-4M AM. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 31067462  Coulombe, P. et al. 2019. Cell Rep. 27: 1769-1780.e4.

PMID: # 24599126  Patenaude, A. et al. 2014. Cancer Res. 74: 2402-11.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Various publications cite DAR Various publications cite DAR-4M AM as a cell-permeable, photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of approximately 10nM. -SCBT Publication Review
Date published: 2015-04-23
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