Dantrolene, Sodium Salt Hemiheptahydrate CAS: 24868-20-0
MF: 2C14H9N4NaO5•7H2O
MW: 798.57
An inhibitor which blocks muscle contraction.

Dantrolene, Sodium Salt Hemiheptahydrate (CAS 24868-20-0)

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Application: Dantrolene, Sodium Salt Hemiheptahydrate is an inhibitor which blocks muscle contraction
CAS Number: 24868-20-0
Molecular Weight: 798.57
Molecular Formula: 2C14H9N4NaO57H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dantrolene, Sodium Salt Hemiheptahydrate, is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene, Sodium Salt Hemiheptahydrate, is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Additionally, Dantrolene, Sodium Salt Hemiheptahydrate, has been shown to inhibit G6PD, RyR-1 and RyR-3 in vitro.


References

1. Harrison, G G., et al., 1988. Malignant hyperthermia. Dantrolene--dynamics and kinetics. British journal of anaesthesia. 60(3): 279-86. PMID: 3279988
2. Ellis, K O., et al., 1980. Synthesis and skeletal muscle relaxant activity of quaternary ammonium salts of dantrolene and clodanolene. Journal of pharmaceutical sciences. 69(3): 327-31. PMID: 7381711
3. Tanii, H., et al., 1997. Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA-binding activity in the rabbit brain following haloperidol administration and heat stress. Psychiatry and clinical neurosciences. 51(6): 415-9. PMID: 9472129
4. Büyükokuroğlu, M E., et al., 2001. In vitro antioxidant properties of dantrolene sodium. Pharmacological research : the official journal of the Italian Pharmacological Society. 44(6): 491-4. PMID: 11735355
5. Beydemir, Sükrü., et al., . Glucose 6-phosphate dehydrogenase: in vitro and in vivo effects of dantrolene sodium. Polish journal of pharmacology. 55(5): 787-92. PMID: 14704475

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in hot water (partly), and DMSO.
Storage :
Store at -20° C
Melting Point :
279-280° C
Boiling Point :
544.5° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.72 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 6.31 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Merck Index :
14: 2816
MDL Number :
MFCD07357270
SMILES :
C1N(C(=NC1=O)[O-])/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].C1N(C(=NC1=O)[O-])/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+]

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Certificate of Analysis

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